Publications

Selected Publications:

19.     Royce W. Zhou, Jia Xu, Tiphaine Martin, Alexis Zachem, John He, Sait Ozturk, Deniz Demircioglu, Ankita Bansal, Andrew Trotta, Bruno Giotti, Berkley Gryder, Yao Shen, Xuewei Wu, Saul Carcamo, Kaitlyn Bosch, Benjamin Hopkins, Alexander Tsankov, Randolph Steinhagen, Drew Jones, John Asara, Jerry Chipuk, Rachel Brody, Steven Itzkowitz, Iok In Christine Chio, Dan Hasson, Emily Bernstein, and Ramon Parsons. A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. Nat. Communications, 13, Article number: 6041 (2022).

20.    Karen Mendelson, Tiphaine C. Martin, Christie B. Nguyen, Min Hsu, Jia Xu, Claudia C.V. Lang, Reinhard Dummer, Yvonne Saenger, Jane L. Messina, Vernon K. Sondak, Garrett Desman, Dan Hasson, Emily Bernstein, Ramon E. Parsons, and Julide Tok Celebi. Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation. JCI Insight, 10.1172/jci.insight.166611 (2024).

18.      Xufen Yu*, Jia Xu*, Kaitlyn M Cahuzac, Ling Xie, Yudao Shen, Xian Chen, Jing Liu, Ramon E. Parsons , Jian Jin. Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells. J. Med. Chem. 2022 Oct 5. doi: 10.1021/acs.jmedchem.2c01454. Online ahead of print. *co-first author

17.      Xufen Yu*, Jia Xu*, Yudao Shen, Kaitlyn M. Cahuzac, Kwang-su Park, Brandon Dale, Jing Liu, Ramon E. Parsons, and Jian Jin. Discovery of potent, selective, and in vivo efficacious AKT kinase Protein Degraders via Structure-Activity Relationship Studies. J. Med. Chem. 2022, 65, 4, 3644–3666, *co-first author

16.      Xufen Yu*, Jia Xu*, Ling Xie, Li Wang, Yudao Shen, Kaitlyn M. Cahuzac, Xian Chen, Jing Liu, Ramon E. Parsons, and Jian Jin. Design, Synthesis and Evaluation of Potent, Selective and Bioavailable AKT Kinase Degraders. J. Med. Chem. 2021, 64, 24, 18054–18081, *co-first author

15.      Jia Xu*, Xufen Yu*, Tiphaine C. Martin, Ankita Bansal, Kakit Cheung, Li Wang, Elias Stratikopoulos, Kaitlyn M. Cahuzac, Ling Xie, Abigail Lubin, Royce Zhou, Yao Shen, Ruifang Qiao, Poulikos Poulikakos, Xian Chen, Jing Liu, Jian Jin*, Ramon Parsons*. AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild-type KRAS and BRAF by destabilizing Aurora kinase B. Cancer Discov. (2021) 11 (12): 3064–3089, *co-first author

14.      Kyrie Pappas, Jia Xu, Sakellarios Zairis, Lois Resnick-Silverman, Francesco Abate, Nicole Steinbach, Sait Ozturk, Lao H. Saal, Tao Su, Pamela Cheung, Hank Schmidt,l, Stuart Aaronson, Hanina Hibshoosh, James Manfredi, Raul Rabadan, Ramon Parsons. p53 maintains baseline expression of multiple tumor suppressor genes. Mol. Cancer Res. 2017;15(8):1051-1062

Chosen as the cover article.

13.      Jia Xu*, Sunil Acharya*, Xiao Wang, Shalini Jain, Hai Wang, Qingling Zhang, Chia-Chi Chang, Joseph Bower, Banu Arun, Victoria Seewaldt, & Dihua Yu.  Downregulation of GLUT4 Contributes to Effective Intervention of Estrogen Receptor-Negative/HER2-overexpressing Early Stage Breast Disease Progression by Lapatinib. Am. J. Cancer Res. 2016;6(5):981-995, *co-first author

12.      Chia-Chi Chang, Chenyu Zhang, Qingling Zhang, Ozgur Sahin, Hai Wang, Jia Xu, Yi Xiao, Jian Zhang, Sumaiyah K. Rehman, Ping Li, Mien-Chie Hung, Fariba Behbod, Dihua Yu. Upregulation of Lactate Dehydrogenase A by 14-3-3ζ Leads to Increased Glycolysis Critical for Breast Cancer Initiation and Progression. Oncotarget, 2016 May 2. doi: 10.18632/oncotarget.9136

11.      Jia Xu, Sunil Acharya, Ozgur Sahin, Qingling Zhang, Yohei Saito, Jun Yao, Hai Wang, Ping Li, Lin Zhang, Frank J Lowery, Wen-Ling Kuo, Yi Xiao, Joe Ensor, Aysegul A Sahin, Xiang H.-F. Zhang, Mien-chie Hung, Jitao David Zhang, & Dihua Yu. 14-3-3ζ turns TGF-β’s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015;27(2):177-92

Comments in:

14-3-3ζ turns TGF-β to the dark side. Cancer Cell. 2015;27(2):151-3.

The Dichotomous Functions of TGFβ in Breast Cancer Are Regulated by 14-3-3ζ. Cancer Discov. 2015 Feb 26

Sanders P: F1000Prime Recommendation of [Xu J et al., Cancer Cell 2015, 27(2):177-92]. F1000Prime, 25 Mar 2015; DOI: 10.3410/f.725353110.793505226. 

Tipping the balance between good and evil: aberrant 14-3-3ζ expression drives oncogenic TGF-β signaling in metastatic breast cancers. Breast Cancer Res. 2015;17(1):92. doi: 10.1186/s13058-015-0603-2

10.      Jia Xu*, Christopher L. Neal*, Ping Li, Seiji Mori, Jun Yang, Nina N. Neal, Shannon L. Wyszomierski, Mien-Chie Hung, & Dihua Yu. Overexpression of 14-3-3zeta in cancer cells activates PI3K via binding the p85 regulatory subunit. Oncogene. 2012;31:897–906, *co-first author

9.      Jia Xu*, Priya B Shetty*, Weiwei Feng, Carol Chenault, Robert C Bast, Jr., Jean-Pierre J Issa, Susan Hilsenbeck, and Yinhua Yu. Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome. BMC Cancer. 2012;12(1):243, *co-first author

8.   Anupam Kumar, Jia Xu, Bokyung Sung, Santosh Kumar, Dihua Yu, Bharat Aggarwal, Kapil Mehta. Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells. Breast Cancer Res. 2012;14(1):R4

7.   Anupam Kumar, Hui Gao, Jia Xu, James Reuben, Dihua Yu, and Kapil Mehta. Evidence that Aberrant Expression of Tissue Transglutaminase Promotes Stem Cell Characteristics in Mammary Epithelial Cells. PLoS One 2011;6(6):e20701

6.   Weiwei Feng, Rosaria Orlandi, Naiqing Zhao, Maria Luisa Carcangiu, Elda Tagliabue, Jia Xu, Robert C. Bast Jr. and Yinhua Yu. Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers. BMC Cancer 2010;10:378

5.   Anupam Kumar, Jia Xu, Samuel Brady, Hui Gao, Dihua Yu, James Reuben and Kapil Mehta. Transglutaminase 2 induces epithelial to mesenchymal transition and promotes tumorigenic phenotype in mammary epithelial cells. PLoS One 2010, 5(10):e13390

4.   Shau-Hsuan Li, Valerie S. Hawthorne, Christopher L. Neal, Sartaj Sanghera, Jia Xu, Jun Yang, Hua Guo, Patricia S. Steeg and Dihua Yu. Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer Res. 2009;69(24):9163–8

3.   Chuanfeng Liu, Fuming Yi, Junping Wang, Xiaochun Wang, Hong Jiang, Jia Xu and Yuanyang Hu. Isolation and RNA1 nucleotide sequence determination of a new insect nodavirus from Pieris rapae larvae in Wuhan city, China. Virus Research 120 (2006) 28–35

2.   Lequan Qiu, Jiamin Zhang, Chuanfeng Liu, Dawei Cai, Jia Xu, Yuanyang Hu. Histopathological and cytopathological changes in Pieris rapae infected by a new nodavirus. Virologica Sinica. 2005;20(6)664-667

1.  Fang Jia, Jia Xu, Yingchao Nie, Yang Xiao, Rui Zhou, Xiaoqing Li, Zehua Yu. Comparison of Heliothis armigera NPV VHA273 wild isolate with its clone. Virologica Sinica. 2003;18(3):241-245